Plastic bottles in the pharmaceutical field

Drugs are a special commodity whose efficacy and quality are directly related to the health and safety of the human body. The packaging materials and structural forms used must ensure efficacy while also serving to ensure the reliability and convenience of drug use. As a drug manufacturer in the selection of packaging materials, it is necessary to understand some properties and characteristics of the packaging materials and containers so as to combine the specific requirements of the drugs and reasonably and accurately select the pharmaceutical packaging materials.

At present, China's tablet drugs such as plain tablets, sugar-coated tablets, including capsules, are packaged in simple plain paper bags, simple plastic bags, transparent and brown glass bottles, and transformed into high-quality plastic bottle packaging and blister packaging. Aluminum plastic unit strip packaging. The packaging materials of this kind have also been continuously improved, and the pharmaceutical solid dosage form packaging is also becoming the product with the highest efficiency and highest technical content in the packaging industry.

In the 1980s, as China continued to introduce advanced pharmaceutical plastic bottle production lines from abroad, the prelude to “plastic” and “glass” began to unfold, from which large-capacity glass bottles and brown bottles gradually withdrew from drug tablets. In this field of pharmaceutical packaging, pharmaceutical plastic bottles are replaced by non-toxic high-molecular polymers such as PE, PP, PC, and PET as main raw materials, and advanced plastic molding processes and equipment are used to produce various medicinal products. Plastic bottles are mainly filled with various types of oral tablets, capsules, capsules and other solid dosage forms and liquid preparations.

The biggest characteristic of medicinal plastic bottles is their light weight, non-breakable, clean, and beautiful appearance. Pharmaceutical manufacturers do not need to be cleaned and dried to use directly. And some of its technical indicators and a large number of data show that its chemical resistance, water vapor permeability and sealing performance is excellent, it can completely protect the loaded drugs in the effective period of the security shield. There are high-density polyethylene bottles (HDPE), polypropylene bottles (PP), polycarbonate bottles (PC), and polyester bottles (PET) in the materials used. In the early 1990s, foreign countries developed blows. The new plastic bottle of polyethylene naphthalate (PEN) plastic bottle is superior to PET in terms of its high strength, good heat resistance, ultraviolet radiation resistance, excellent carbon dioxide gas and oxygen barrier properties, and chemical resistance Drugs have good performance and are more widely used than PET. PEN is a new type of polyester resin actively developed at home and abroad in recent years, and it is also an excellent material for pharmaceutical plastic bottle packaging.

Because of the many specifications of medicinal plastic bottles, small dozens of milliliters, large thousands of milliliters, there is no color, there are transparent, colorful, various shapes, a wide range of categories. Faced with the brilliant market of plastic bottles, as a drug manufacturer, the following principles are mainly taken into consideration when selecting plastic bottles:

l, choose the plastic bottle main raw materials, additives formula: solid plastic bottles of product standards, respectively, provides the applicable main raw materials, and must comply with non-toxic, no odor and other requirements, due to the selection of the main raw materials, there are many , This requires the selection of the raw material's comprehensive performance. Generally, the tablet is made of high-density polyethylene and polypropylene bottles. If transparency is needed, PET bottle can be used. If the drug needs to have higher barrier properties, and light blocking and opaque, brown is selected. PET bottles, better barrier performance PEN bottle. Liquid formulations of drugs generally use polypropylene bottles or polyester bottles as the main raw material.

2, plastic bottle product quality standards. From the production plant's product quality standards can be analyzed and judged the pros and cons of product quality. Pharmaceutical plastic bottle companies should establish corporate standards that are stricter than national standards and industry standards.

3, bottle body and cover seal, water vapor permeability. Sealability and water vapor permeability are two important technical indicators of medicinal plastic bottles, and they play an important role in the stability of charge.

4, quality assurance system. Auditing suppliers has become an essential part of purchasing plastic bottles. Through the audit, a comprehensive and correct assessment of the integrated level of the software and hardware facilities, technical equipment, and quality of the production plant can be made.

5, plastic bottle charge stability and compatibility. The use of plastic bottles, especially new drug selection of new plastic bottles (or new materials, new processes) should be carried out to test drug loading in order to investigate the stability of the charge and the compatibility between the plastic bottle and the drug. The penetration, dissolution, adsorption, chemical reaction, and denaturation of drugs and plastic bottles must be determined through scientific tests.

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