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Telomeres are DNA sequences at the ends of chromosomes, which gradually shorten with each division of the cell, reflecting the aging of the organism. RAP1 is part of the shelterin protein complex, which is a cap-like structure that protects telomeres. The researchers conducted an in-depth study of six kinds of shelterin proteins and found that RAP1 is not a protein necessary for biological survival, which is different from several other shelterin proteins.
But this does not mean that the RAP1 protein is not important. The researchers compared the genomes of different species and found that RAP1 is the most conserved among all shelterin proteins. They pointed out that during a long evolutionary process, RAP1 has not changed, it even exists in yeast. Such conservatism usually indicates that the molecule has an important role in the organism.
CNIO researchers found that RAP1 also appears in other parts of chromosomes in addition to telomeres. They speculate that RAP1 can regulate the activity of other genes. In order to study the potential function of RAP1 and clarify its importance in biology, the researchers constructed a mouse line lacking RAP1. To their surprise, these mice showed the typical characteristics of obesity.
"Mice lacking RAP1 did not increase their food intake, but their body weight increased significantly. Among them, the reaction of female mice was more obvious. We found that these mice have metabolic syndrome and therefore exhibit various obesity symptoms , Including abdominal fat accumulation, excessive glucose and cholesterol levels, etc., "said Paula MartÃnez, the first author of the article.
The researchers found that RAP1 can regulate important metabolic related genes and affect key signaling pathways. "This discovery adds new factors to obesity research and reveals the internal link between metabolic disorders and aging," Blasco said. Next, they will deeply analyze the role of RAP1 in human obesity.
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