1405-41-0, gentamicin sulfate use instructions

Name: Gentamicin Sulfate, Orthomycin, Tacrolimus Sulfate CAS Number: 1405-41-0 Molecular Formula: C21H43N5O7·H2SO4 Molecular Weight: 575.67 g/mol Grade: USP Grade Potency: ≥590 U/mg pH (4% in Water) at 25°C: 3.5 – 5.5 Specific Optical Rotation: +107° to +121° Appearance: White or off-white crystalline powder, odorless Melting Point: 218 – 237°C Hygroscopic: Yes Solubility: Soluble in water; insoluble in ethanol, ether, or chloroform Storage: 2 – 8°C Gentamicin sulfate is a broad-spectrum aminoglycoside antibiotic commonly used in biochemical research and clinical settings. It works by binding to the 30S ribosomal subunit of bacterial cells, which disrupts protein synthesis and leads to a code error during translation. This mechanism prevents the transfer of peptidyl-tRNA from the acceptor site to the donor site, ultimately inhibiting bacterial growth. In addition to its effect on the ribosome, gentamicin exerts a bactericidal action against *Pseudomonas* species by interacting with the outer membrane of the bacterial cell. It replaces existing cations in the membrane, causing structural instability and the formation of pores or voids on the cell surface, leading to cell death. The antibiotic has a wide antibacterial spectrum, effective against Gram-negative bacteria such as *Escherichia coli*, *Klebsiella*, and *Pseudomonas*, as well as some Gram-positive organisms like *Staphylococcus*. Due to its potent activity, it is often used in treating severe infections, especially those caused by multidrug-resistant pathogens. Proper storage is essential to maintain the stability and efficacy of the compound. It should be kept in a cool, dry place, away from light, heat, and moisture. The product is typically available in powder form and can be reconstituted in sterile water for use in laboratory or medical applications. Always handle with care and follow safety guidelines when working with this compound, as aminoglycosides can be toxic to renal and auditory systems if misused.

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