1405-41-0, gentamicin sulfate use instructions

**Product Name:** Gentamicin Sulfate, Orthomycin, Tacrolimus Sulfate **CAS Number:** 1405-41-0 **Molecular Formula:** C₂₁H₄₃N₅O₇·H₂SO₄ **Molecular Weight:** 575.67 g/mol **Grade:** USP Grade **Potency:** ≥590 U/mg **pH (4% in Water) at 25°C:** 3.5 – 5.5 **Specific Optical Rotation:** +107° to +121° **Appearance:** White or off-white crystalline powder, odorless **Melting Point:** 218 – 237°C **Hygroscopic:** Yes **Solubility:** Soluble in water; insoluble in ethanol, ether, and chloroform **Stability:** Stable under light, heat, and pH conditions **Usage:** Widely used in biochemical research **Mechanism of Action:** Gentamicin exerts its antibacterial effect by binding to the 30S ribosomal subunit, thereby interfering with protein synthesis and causing a reading error during translation. Additionally, it targets the outer membrane of Gram-negative bacteria like *Pseudomonas*, displacing cations and destabilizing the membrane, which leads to the formation of pores and ultimately cell death. **Antibacterial Spectrum:** Effective against Gram-negative bacteria, as well as some Gram-positive organisms such as *Staphylococcus*. **Storage:** Store at 2–8°C in a cool, dry place away from moisture and direct light. This product is commonly used in microbiological studies and drug development due to its strong bactericidal activity and well-documented mechanism. Proper storage is essential to maintain potency and stability over time. Always handle with care and follow safety guidelines when working with antibiotics.

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