Glycoprotein secreted by A. umbellatum is associated with apoptosis of human vascular endothelial cells

The pathogenic feature of Mucor fungus is vasophilia, which can induce necrosis and thrombosis of the involved blood vessels, resulting in ischemic necrosis of the organs and tissues at the innervation site of the blood vessels. Our previous studies confirmed that Mucor umbellatum belonging to Mucor can induce apoptosis of human umbilical vein endothelial cells (HUVEC) in a time-dependent manner in vitro, and the signaling of this apoptosis is mediated by the caspases cascade of. In this experiment, we will continue to explore whether the apoptosis of HUVEC induced by A. umbellatum is related to the virulence factors it secretes, and further analyze the transmission pathway of apoptosis signals.

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