![<?echo $_SERVER['SERVER_NAME'];?>](/template/twentyseventeen/skin/images/header.jpg)
Apoptosis is a basic biological phenomenon of cells, which plays an important role in the evolution of biology, the stability of the internal environment and the development of multiple systems. K + is the main cation in the cell, and K + outflow will occur during apoptosis. Preventing the loss of K + can effectively inhibit the development of apoptosis. In 2009, scientists in Mexico and Australia used "non-damaging micro-measurement technology" and patch clamp to study apoptosis, and found that 1μM STS (cross-sporine) will quickly cause K + outflow, peaking in about 15 minutes, and then weakened. At the same time, it was recorded that the current of the Kbg channel increased, accompanied by a sharp decrease in membrane depolarization. The current of Kv1.3 is not affected by STS, but this inactive channel is converted to more positive potential. The contribution of Kbg and Kv1.3 channels to STS-induced K + outflow has a chronological relationship. Bupivacaine (bupivacaine) mainly inhibits Kbg current, and margatoxin (margaret toxin) is a specific inhibitor of Kv1.3. The channel regulates the K + outflow to cause the contraction of the cell, activating the cysteine ​​protease (apoptosis protease), so that the cell changes from a normal physiological state to an apoptotic physiological state, and then to a non-physiological state. The environment inside the cell changes rapidly, such as cell size, membrane potential, pH, and Ca2 + concentration, and the mechanism of K + regulation is crucial in the change of the cell environment. The Kbg channel regulates the early K + outflow. The Kv1.3 channel plays a major role in the later period. After the K + outflow is inhibited, it completely stops, and the activity of caspase-3 also changes. This research provides new evidence for understanding the internal mechanism of apoptosis. This real-time and easy-to-operate research method is expected to diagnose or detect apoptotic cells in clinical and other practical applications. Keywords: staurosporine (STS, staurosporine), Jurkat cells (T cells), Kbg and Kv1.3 channels References: Valencia-Cruz G, et al. Am J Physiol Cell Physiol, 2009, 297: C1544–C1553
Basswood shutter Components are made of high-quality basswood material with excellent durability and stability. Its structural design is exquisite, including louvers, connecting rods, drawstrings and other components, which can effectively adjust indoor light and ventilation. The surface of the shutter parts has been finely polished and painted, making it smooth and delicate, with a natural color. It is easy to install and operate. The opening and closing angle of the louver can be freely adjusted according to actual needs to achieve personalized light control. Basswood shutter components not only have a beautiful appearance, but also have good heat and sound insulation effects. They are a high-quality window decoration product suitable for various places such as homes and offices.
1. shutters blade: It is the main component of the blind, used to adjust the angle of sunlight and control the brightness of indoor light.
2. shutters track: supports the blind blades so that they can open, close and rotate smoothly.
3. shutters controller: used to manually or electrically control the opening, closing and rotation angle of the shutters.
4. Louver blades: connected to the shutters blades to increase the sealing and sound insulation effect of the shutters
5. Shutter frame: supports the entire shutter structure to ensure its stability and durability.
6. shutters fixings: Used to fix the position of the shutters to prevent them from being damaged or moved in wind and rain.
Basswood Shutters Components,Plantation Basswood Timber Shutters Components,Basswood For Shutters,Basswood Timber Shutters Components
Huaian Huiyuan Wooden Products Co.,Ltd , https://www.hyshutters.com