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Oncogene, the international authoritative journal of oncology research, recently published the latest research results of Zhang Yanyun's research group at the Institute of Health Sciences: "Identification of G-Protein Coupled Receptor 120 as a Tumor-Promoting Receptor that Induces Angiogenesis and Migration in Human Colorectal Carcinoma". This study revealed for the first time the role and mechanism of fatty acid receptor G-protein coupled receptor 120 (GPR120) in the progression of human colorectal cancer.
A series of GPRs are considered to be free fatty acid receptors (FFAR), and these receptors play an important role in physiological self-stability. Among them, GPR120 is the most mysterious member of the FFAR family, and its endogenous ligand is polyunsaturated long-chain fatty acid. GPR120 can regulate the secretion and inflammation of intestinal hormones such as cholecystokinin and glucagon. Due to its potential regulatory role in metabolic and inflammatory diseases such as obesity and type 2 diabetes, the function of GPR120 has attracted widespread attention.
Dr. Qiong Wu, a postdoctoral fellow under the guidance of researcher Zhang Yanyun, found that GPR120 is highly expressed on colorectal cancer cell lines and human colorectal cancer tissues, and is closely related to tumor progression; In-depth research found that the activation of GPR120 signal can promote tumor angiogenesis and tumor epithelial mesenchymal transformation and migration; at the same time, it revealed that the role of GPR120 signal in promoting tumor angiogenesis depends on the PI3K / Akt-NF-κB signaling pathway activation. The study revealed for the first time that GPR120 is a FFAR that promotes the progress of human colorectal cancer, provides a new concept for the study of lipid metabolomics and tumorigenesis, and also suggests that GPR120 is a potentially important target for colorectal cancer treatment. .
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