![<?echo $_SERVER['SERVER_NAME'];?>](/template/twentyseventeen/skin/images/header.jpg)
At present, in the global prescription drug market, anti-tumor drugs have the fastest growth momentum. It is reported that it will surpass hypolipidemic drugs to become the market sales champion in the past 1-2 years. Antitumor drugs are divided into alkylating agents, antimetabolites, antibiotics, natural sources, hormones and other types. The objects HD and HD-M analyzed in this protocol belong to natural source antitumor drugs with molecular weights of 490 and 314, respectively, where HD-M is a metabolite of HD. Currently in the process of research and development of new drugs, the compound name and structure belong to the confidential stage. In the scheme, Shimadzu ultra-high performance liquid chromatograph LC-30A and triple quadrupole mass spectrometer LCMS-8030 were used in combination to quickly determine the anti-tumor drugs HD and HD-M, and the results of linear range, repeatability and sensitivity were given.
In this scheme, Shimadzu Ultra High Performance Liquid Chromatograph LC-30A and triple quadrupole mass spectrometer LCMS-8030 are used in combination. The specific configuration is LC-30AD × 2 infusion pump, DGU-20A5 online degasser, SIL-30AC automatic sampler, CTO-30AC column thermostat, CBM-20A system controller, LCMS-8030 triple quadrupole mass spectrometer , LabSolutions Ver.5.41 chromatography workstation. The Shimadzu triple quadrupole mass spectrometer LCMS-8030 ultra-fast analysis device achieves ultra-fast MRM measurement with a maximum of 500 channels / second (minimum residence time 1msec, minimum delay time 1msec) and positive and negative polarity switching time 15msec, up to 15000 u / sec ultra-fast scanning determination. In high-speed analysis, the UFsweeper® collision cell that can suppress crosstalk is combined with NexeraTM LC-30A to improve the analysis throughput and increase the user's analysis efficiency. Equipped with high-reliability ionization interface, it can obtain stable and reliable data in long-term measurement. Accurately capture the sharp peaks in ultra-fast LC analysis to improve reproducibility. Minimizing crosstalk in the collision cell ensures high quantitative accuracy.
Shimadzu Ultra High Performance Liquid Chromatograph LC-30A and Triple Quadrupole Mass Spectrometer LCMS-8030 Combined System
This protocol uses Shimadzu Ultra High Performance Liquid Chromatograph LC-30A and triple quadrupole mass spectrometer LCMS-8030 to quickly determine the anti-tumor drug (code HD) and its metabolites (code HD-M). The samples were separated by ultra high performance liquid chromatography LC-30A, and the triple quadrupole mass spectrometer LCMS-8030 was used for external standard method quantitative analysis, and the detection was completed within 1.2 minutes. HD is in the range of 0.05 ～ 50μg / L, HD-M is in the range of 0.1 ～ 10μg / L, and the correlation coefficient of the standard curve is above 0.999; for 0.5μg / L, 5μg / L and 50μg / L mixed standard solutions For precision experiments, the retention time and relative standard deviation of peak area for 6 consecutive injections are below 0.182% and 2.780%, respectively, and the system precision is good; HD quantitation limit is 0.005μg / L, HD-M quantitation limit is 0.1μg / L.
For more information, please click—Ultra High Performance Liquid Chromatography Triple Quadrupole Mass Spectrometry to determine antitumor drugs and their metabolites.
The designs of our modern benches come from the most famous designers in the world, it looks simple but nice and durable. When we produce modern benches, our skilled technicians take care of every details, so it looks in super quality and very close to the original.Our modern benches are not only suitable for your bedroom,but also suitable for hotel,villas,clubs. Welcome all the consumers from all over the world to buy the modern benches from us ,you can put it for own use, also can resell it to make some profit.
Modern Bench,Competitive Modern Bench,Arc-Shaped Modern Bench,Modern Long Wooden Bench
Shenzhen Yadea furniture Co. Ltd. , https://www.modernluxuryfurniture.com