Can vitamin D relieve asthma and atopic dermatitis?

According to a new study published by PLOS Medicine of Brent Richards of McGill University in Canada, vitamin D supplements are unlikely to reduce the risk of asthma, atopic dermatitis or allergies in children or adults.

Some previous epidemiological studies have shown that low vitamin D levels are associated with elevated levels of asthma, atopic dermatitis (inflammation of the skin), and elevated levels of IgE (immune molecules associated with atopic disease (allergy)). In the new work, researchers have studied genetic and health data from more than 100,000 people from previous large studies to determine whether genetic changes associated with vitamin D levels can cause asthma, dermatitis or elevation. IgE level.

The researchers found that among any of the four genetic changes associated with lower levels of 25-hydroxyvitamin D, asthma (including childhood onset asthma), between atopic dermatitis or IgE levels There were no statistically significant differences. However, the results do not rule out the association between the results and levels of 1,25-dihydroxyvitamin D (the active form of vitamins) and require more work to determine if the results of non-European population and vitamin D deficiency are correct.

Dr. Despoina Manousaki, lead author of the Davis Institute, said: "Our findings suggest that the association between previous vitamin D and atopic disease may be due to false associations with other factors." Efforts to increase vitamin D levels may Does not cause adult and pediatric asthma, a reduced risk of atopic dermatitis or elevated IgE levels.

These findings, in contrast to a recent study in the same group, used similar methods to provide evidence supporting the causal role of vitamin D in the risk of multiple sclerosis, a common neurological disorder. Dr. Richards said: "Our previous findings suggest that low vitamin D levels increase the risk of some inflammatory diseases such as multiple sclerosis, but these effects do not translate into other inflammatory diseases such as asthma and atopic dermatitis. The risk of multiple sclerosis is elevated in some populations, including European descent and white women, and these findings suggest that people at risk for multiple sclerosis should ensure adequate vitamin D levels but increase vitamin D. Efforts will not prevent asthma.

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