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South Africa has the highest incidence of tuberculosis in the world. In 2007 alone, 112,000 people died of tuberculosis. The reason is that about 80% of tuberculosis patients in South Africa are co-infected with HIV. Due to the long treatment cycle (generally 6 to 9 months), it is difficult for most patients to fully comply with the treatment requirements. Coupled with the poor biological activity and side effects of tuberculosis treatment drugs themselves, the patient develops drug resistance, such as multiple drug-resistant tuberculosis (MDR-TB).
The meeting introduced the gratifying results of the nano-drug research center led by Dr. Harda Swai in the delivery of anti-tuberculosis nano-drugs. They developed a "target drug delivery system" based on nanotechnology, using a new multi-emulsion spray drying technology, wrapped four drugs currently used to treat tuberculosis in polymers, and made drug particles with a size of about 250 nanometers. . This drug can make it easier for antibiotics to find their target, enter macrophages infected by tuberculosis bacteria, release antibodies for a long time, and promote the absorption of antibodies by cells. This can reduce the dose and frequency of anti-tuberculosis drugs, while improving patient compliance.
For patients with MDR-TB, this nanomedicine is of particular importance. Because according to conventional treatment methods, patients with MDR-TB take 14 tablets per day for up to 2 years, the treatment cost is tens or even hundreds of times higher than that of ordinary patients, and the mortality rate reaches 50% within 1 to 2 years. If you use the nano tablets, you only need to take 2 tablets per week, and the cycle is only 2 months. Therefore, nanomedicine will provide a simple, fast, safe and affordable treatment for MDR-TB patients. Recently, the African Pharmaceutical and Diagnostic Innovation Association awarded the center the title of "Pharmaceutical Innovation Center of Excellence". The center has expanded the technology to the research and development of anti-AIDS nano-drugs and anti-malarial nano-drugs.
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