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According to the physicist organization network recently, scientists at Stanford University in the United States have developed a fluorescence imaging technology that can make blood vessel pulsations in live animals appear with unprecedented clarity. Compared with traditional imaging technology, the increased sharpness is similar to the fog in front of the glasses. The results of this study were published in the latest edition of the online edition of the journal Natural Medicine.
This technique is called NIR-II imaging, or NIR-II. The researchers first injected water-soluble carbon nanotubes into the blood of living bodies, and then irradiated the objects to be observed, such as mice, with laser light. The wavelength of the laser is in the near infrared range, about 0.8 microns, which can cause specially designed carbon nanotubes to emit longer-wavelength fluorescence from 1 micron to 1.4 microns, which is used to detect and determine the structure of blood vessels.
The wavelength of fluorescence emitted by carbon nanotubes is longer than that of traditional imaging technology, which is the key to achieving amazing clear images of tiny blood vessels. Since the longer wavelength light scatters less, a clearer blood vessel image is formed. In addition, this technique allows images to be presented with more refined details, allowing researchers to obtain a fast image acquisition speed and measure blood flow in near real time.
Obtaining blood flow information and seeing clear blood vessels at the same time will be particularly useful for studying animal models of arterial disease, such as how blood flow is affected by arterial occlusion and contraction, and other issues such as stroke and heart attack.
The researchers said: "For medical research, this is a very good tool for observing the characteristics of small animals. It will help us better understand some vascular diseases, as well as their response to treatment and how we can design more Good treatment. "
Since NIR-â…¡ can only penetrate at most 1 cm of the body, it will not replace other imaging technologies, but it is complementary to X-ray, CT, MRI and laser Doppler technology. However, it is a powerful method for studying animal models.
The researchers say that the next step will be to make the technology more acceptable in the human body and explore alternative fluorescent molecules. They hope to find substances that are smaller than carbon nanotubes and can emit light at the same wavelength, so that they can be easily excreted from the body, eliminating any toxic concerns.
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