FDA approves the world's first new drug to treat irritable bowel syndrome

The US Food and Drug Administration (FDA) has approved the world's first guanylate cyclase agonist linaclotide (Linaclotide) in the United States for clinical treatment of constipation irritable bowel syndrome or chronic Hairstyle constipation. AstraZeneca, headquartered in London, United Kingdom, and Ironwood Pharmaceuticals, headquartered in Massachusetts, will work together to promote the new drug in the Asia-Pacific market, including China.

The main symptoms of constipation-type irritable bowel syndrome are abdominal pain and constipation. It is a common chronic functional gastrointestinal disease, and currently treatment is limited. Studies have suggested that an increase in intracellular cyclic guanosine phosphate (cGMP) concentration can stimulate the secretion of intestinal fluid and promote gastrointestinal activity, resulting in an increase in the number of bowel movements; non-clinical experimental model data shows that an increase in extracellular cGMP concentration is considered to be reduced The activity of the pain sensory nerves, thereby reducing intestinal pain.

Linaclotide, developed by the researchers of Tetrakisporin, is a guanylate cyclase agonist (GCCA), which binds to guanylate cyclase C in the intestine, thereby enabling intracellular and extracellular cGMP The increased concentration can achieve the purpose of treating constipation irritable bowel syndrome. It is understood that the iron-wood medicine has submitted a phase III clinical trial application to China's State Food and Drug Administration (SFDA) in order to evaluate the effectiveness and safety of linaclotide in the treatment of adult patients with constipated irritable bowel syndrome. Sex. Mark Malone, vice president of AstraZeneca Asia Pacific and president of China, said: "Linalotide provides patients with a new option for the treatment of constipation."

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