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According to a study done by researchers at the University of California, San Francisco, a reduction in the level of a key brain protein can inhibit the behavior of drinking and drinking in rats and mice.
Scientists have discovered that the protein of the H-ras gene is a promising new drug target to treat alcohol abuse. The research was published in the Journal of Neuroscience on November 7.
The research led by Dr. Dorit Ron found for the first time that alcohol intake significantly increased the level of H-ras gene in the nucleus accumbens of animals. The nucleus accumbens is an area of ​​brain activity that regulates rodent and human reward systems, affecting alcohol People's cravings for addiction.
Then, they found that targeted viruses acted on the mouse H-ras gene, and after inhibiting the level of the nucleus accumbens H-ras gene, the mouse alcohol consumption decreased.
Then, the researchers gave animals FTI-276, which has been shown to suppress H-ras gene production. As a result, they observed a significant reduction in alcohol consumption.
More importantly, when the H-ras gene is suppressed, the consumption of alcohol, sugar liquid, saccharin and quinine is not reduced. Studies have shown that the H-ras gene is a possible target for treating alcohol abuse
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