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"Eat seven times full"-control the intake of diet, can make healthier points. Dieting has proven to be effective in delaying aging and prolonging life in many species, and obesity caused by overnutrition can induce many metabolic diseases related to aging, such as diabetes, cardiovascular and cerebrovascular diseases, and even certain tumors.
In order to further explore the biological principles of nutrition, dieting and exercise in the regulation of aging, the research team of Liu Yong, a researcher of the Institute of Nutritional Sciences, Chinese Academy of Sciences, Shanghai Academy of Sciences, applied low-fat and high-fat diets in the previous work to establish "Eating", "30% diet (seven full)" and "free eating plus voluntary exercise" mouse research models found that low-fat diet can significantly extend the lifespan of mice, "seven full" diet intervention can play " "Longevity and longevity" effect. In collaboration with the team of Han Jingdong, a researcher at the Institute of Computational Biology, Chinese Academy of Sciences, the Chinese Academy of Sciences, in the bioinformatics analysis of the gene transcriptome of liver in middle-aged mice, several gene expression programs and signals involved in the regulation of aging and longevity were discovered The pathway provides new enlightenment for in-depth understanding of the mechanism relationship and biological basis between nutritional metabolism and longevity (PNAS Plus 109: E1201-9, 2012).
Recently, Liu Yong's research group applied the mouse model, and cooperated with the research team of Professor Zhao Liping of Shanghai Jiaotong University and Professor Zhao Guoping of the National Center for Human Genome South to carry out exploration research on intestinal flora, and found that dieting can significantly change intestinal bacteria Structural distribution of the group: Among the bacterial groups that are positively related to lifespan, many are proven beneficial bacteria, such as lactobacilli that are positively related to lifespan in low-fat feeds; and among the bacterial groups that are negatively related to lifespan, There are many potential pathogens that may be associated with disease occurrence. Regardless of the low-fat or high-fat diet group, dieting significantly increased the bacterial population positively related to longevity and decreased the bacterial population negatively related to longevity. These results suggest that dieting may promote host health and extend host life by creating a healthier gut flora. The results of these studies were published in the journal Nature-Communication on July 16.
This cooperative research was funded by the Ministry of Science and Technology, the National Natural Science Foundation of China, the Chinese Academy of Sciences and other departments.
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